Phase 1 Capability
Multi-centres Phase 1 studies
Phase 1 population: Solid tumours (all types), haematological malignancies, adult.
Phase 1 Mechanisms: Chemoprevention, angiogenesis inhibitors, immunotherapy, monoclonal antibodies, bioreductives.
Centre specific translational research interest
Chemoprevention biomarker development; Radio and chemosensitivity testing; cancer cell signalling pathways (lung mesothelioma, breast, colon, pancreas); angiogenesis inhibitors; imaging studies for determination of efficacy; breast cancer prediction of risk.
Technology/equipment within the centre
Tissue and DNA banking (-80°C and liquid nitrogen) and tissue processing facilities
Analytical chemistry for biomarker development and pharmacokinetic assays are provided by 4 state of the art mass spectrometer
Genotoxicity assays (inc. Comet assay & immunoassays
Image analysis system based on a GCP compliant computer system
Six 1.5 T clinical MRI scanners: one Siemens Avanto and four Siemens Symphony (with Quantum gradients) systems.
Access to other Facilities and Resources
Clinical trials infrastructure for early phase studies, tissue bank with storage of urological, breast and hepatobilliary malignancies, and extensive laboratories for biomarker development.
In the wider community at the University of Leicester we have access to core facilities for gene targeting and transgenics, confocal microscopy, DNA Sequencing, SNP Genotyping, microarray, Proteomics and Mass Spectrometry, Protein Sequencing and Bioinformatics. We have access to both X- and γ-ray irradiation facilities.
We also have a designated laboratory for the preparation of samples for AMS analysis and access to the AMS facility at Lawrence Livermore National Laboratory, California, US.
Tissue Banking Activity is via the Centre's own tissue bank.
Contact: Jim Strupish
tel: +44 (0) 116 252 3238, email: email@example.com