Our aim is to build upon the advances that have been achieved as a result of our NTRAC programme to further facilitate effective translational research in experimental cancer medicine within the Centre for Cancer Research and Cell Biology (CCRCB) at Queen's University Belfast (QUB).

Our overall objectives are:

• To link major aspects of our laboratory and clinical research programme through translational research;
• To build the necessary infrastructure to expand our activity in translational research and early phase clinical trials;
• To develop biomarkers for prognostication and prediction of response and toxicity;
• To apply functional imaging technologies in the monitoring of response to novel therapeutic agents.

Clinical Trials - Oncology/Haematology

• Early clinical trials including first-in-human studies, in any advanced malignancy and disease specific phase I and II trials in first, second and third-line treatment of solid tumours and haematological malignancies
• Late phase trials in our disease areas and radiation oncology
• Gene expression profiling for disease classification and diagnosis

Pathology

• Tissue banking
• Molecular imaging
• Molecular diagnostics

Translational Oncology

• Functional imaging
• Genomics
• Grid informatics
• Medicinal chemistry
• Protein engineering

Radiation Oncology

• Early clinical trials in prostate cancer including the use of targeted radionuclides
• Links with Medical Physics, Radiobiology, Molecular Oncology, Mathematical Modeling, Imaging and Atomic Imaging