Phase 1 population

Solid tumours or haematology; adults only

Mechanisms studied

TKI, mTOR inhibitors, angiogenesis inhibitors, sulfatase inhibitors, proteasome inhibitors, epothilones

First-in-Man studies

Yes

Centre specific translational research interest

Metabonomics, epigenetics, pharmacogenomics, drug resistance

Multi-centre Phase 1 studies

Yes

Development of a GCLP facility

Focusing on the biological endpoints used as primary or secondary endpoints of clinical trial to be validated to Good Clinical Laboratory Practice (GCLP)

Optical coherence tomography, PET chemistry/imaging

Lung Cancer

Collection of tissue, blood and urine samples for development of novel biomarkers of response and survival using epigenetic, metabonomic and other approaches. We are also collecting tissue at presentation and on relapse to identify novel drug resistance targets.

Ovarian Cancer Centre

Establishment of our ovarian tissue and blood sample collection to underpin biomarker research in our new Ovarian Cancer Action Centre.

Tissue Banking Activity

Charing Cross and Hammersmith Hospital Tissue Bank

• Charing Cross
• Hammersmith
• Queen Charlottes & Chelsea
• St Mary's