Phase 1 population

Solid tumour and haemato-oncology

Mechanisms studied

RTK inhibition (EGFR/HER2; VEGFR)

First-in-Man studies

Yes

Centre specific translational research interest

• Molecular pathogenesis of Cutaneous Lymphoma and Melanoma; basal-like breast cancer
• FLIM and FRET assays in optical proteomics
• Epigenetics
• Gene therapy
• Small molecules in haematological malignancies

Multi-centre Phase 1 studies

Yes, if appropriate environment available

• CT/PET
• SPECT/CT gamma camera imaging
• Radiochemistry, radiopharmacy, imaging facilities (for chemical synthesis, pre-clinical development and GMP production of imaging agents and radionuclide therapy agents)

CRFs being developed on all three campuses of KCL.

Tissue Banking Activity

Guys & St Thomas Breast Tissue & Data Bank: HTA licensed bank collected over the last 30 years with 7,200 fixed, paraffin-embedded primary tumours, 2,500 frozen primary tumours, and 900 matched tumour and blood DNA samples. All samples have associated, prospectively acquired pathological and clinical data.
National Leukaemia Cell Bank and Myelodysplastic repository held on the Denmark Hill campus
Cutaneous lymphoma tissue bank and developing melanoma tissue bank.

Centre contact responsible for sample collection

Cheryl Gillett (Tissue Bank Manager & HTA Designated Individual)
Nigel Westwood (Leukaemia Bank)
Tracey Mitchell (Skin Bank)

• Guys and Thomas' NHS Foundation Trust
• Kings Hospital NHS Foundation Trust