Phase 1 population

Adult solid tumours and haematology/lymphoma

Mechanisms studied

Wide range of mechanisms

First-in-Man studies

Yes

Centre specific translational research interest

• Increase the number and quality of early phase clinical trials
• Develop informative biomarkers (discovery, optimisation, validation, PK/PD, biological effective dose)
• Develop and validate generic indicators of tumour apoptosis and anti- angiogenesis
• Develop clinical proteomics/metabolomics
• Conduct early phase Clinical Immunology trials and translational PD
• Develop, integrate and expand imaging methodologies in preclinical models and early clinical trials.
• Increase capability to deliver targeted radiotherapies
• Develop radiogenomics and image guided radiotherapy
• Integrate GCLP compliant Laboratory QA systems into early clinical trials

Multi-centre Phase 1 studies

Yes

• Pharmacodynamics and pharmacokinetics to GCLP
• PET imaging, MRI imaging
• Radiotracer design and manufacture
• Genomics and molecular pathology
• Proteomics

• Manchester Cancer Research Centre (MCRC)
• Wolfson Molecular Imaging Centre (WMIC)

Tissue Banking Activities

• Multiple tumour specific banks
• Integrated Banking facilities are in development within the MCRC

Centre contact responsible for sample collection

Professor Noel Clarke
Professor of Surgery and Consultant Urological Surgeon
Division of Cancer Studies, University of Manchester
Christie Hospital Foundation Trust
Wilmslow Road
MANCHESTER
M20 4BX
Tel: 0161 446 3640